Joaquim Segalés

2 months ago | nature.com | Daniel Perez-Zsolt |Edurne García-Vidal |Gerardo Ceada |Dàlia Raïch-Regué |Laia Soler |Sonia Guil | +11 more

AbstractPlitidepsin is an antitumoral compound safe for treating COVID-19 that targets the translation elongation factor eEF1A. Here we detect that plitidepsin decreases de novo cap-dependent translation of SARS-CoV-2 and non-viral RNAs but affects less than 13% of the host proteome, thus preserving cellular viability.

Mar 20, 2024 | nature.com | Marco Brustolin |Nuria Pedreno-Lopez |Jordi Rodon |Víctor Urrea |Edwards Pradenas |Anna Pons-Grífols | +10 more

AbstractSafe and effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are crucial to fight against the coronavirus disease 2019 pandemic. Most vaccines are based on a mutated version of the Spike glycoprotein [K986P/V987P (S-2P)] with improved stability, yield and immunogenicity. However, S-2P is still produced at low levels.