2 Minute Medicine

2 Minute Medicine® was established in 2012 by Dr. Marc D. Succi, a physician affiliated with Harvard Medical School and Massachusetts General Hospital. The aim was to address the need for reliable curation and precise reporting within the medical literature landscape. Each report from 2 Minute Medicine is authored and peer-reviewed by a medical professional. Initially, the focus was on creating brief, curated summaries of studies to help doctors stay informed about new medical findings. However, the organization quickly expanded its reach globally, recognizing a widespread demand for objective, high-quality, and concise medical reporting beyond just Harvard. At the core of our content is a unique tiered reporting system. Summaries are neatly organized in a format we call the “2 Minute Rundown,” similar to what one might share with colleagues in a hospital setting. We prioritize high-quality evidence, selecting information from systematic reviews, meta-analyses, randomized trials, and a select few high-quality observational studies. For those wanting more detail, our In-Depth sections provide comprehensive insights.

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Articles

Sotorasib plus panitumumab may be a promising treatment option for colorectal cancer

1 week ago | 2minutemedicine.com | Simon Pan |Alex Chan

1. While not statistically significant, the use of sotorasib plus panitumumab may have a 30% relative risk reduction in the risk of death compared to the investigator’s choice of chemotherapy in the management of Kirsten rat sarcoma viral oncogene homologue (KRAS) glycine-to-cysteine mutation at codon 12 (KRAS G12C) colorectal cancer.
Spot capillary HbA1c testing may have a role in early detection of type 2 diabetes

2 weeks ago | 2minutemedicine.com | Paary Balakumar |Alex Chan

1. In high-risk patients, point-of-care capillary HbA1c was superior to venous HbA1c as uptake was double, leading to faster results, fewer repeat visits, and identified more undiagnosed Type 2 Diabetes Mellitus. Evidence Rating Level: 1 (Excellent)This cluster randomized controlled trial evaluated point-of-care capillary HbA1c (POC-cHbA1c) versus standard venous HbA1c (vHbA1c) for type 2 diabetes (T2D) screening across 8 Hong Kong primary care clinics.
Nivolumab plus ipilimumab improves progression-free survival in metastatic colorectal cancer

3 weeks ago | 2minutemedicine.com | Neel Mistry

1. Progression-free survival was significantly greater in the nivolumab plus ipilimumab group compared to nivolumab alone. 2. Treatment-related adverse events were slightly higher in nivolumab plus ipilimumab. Evidence Rating Level: 1 (Excellent) Study Rundown: Microsatellite instability-high metastatic colorectal cancer is an aggressive disease with limited treatment options.
Less frequent mammography is non-inferior to annual screening for breast cancer survival in women after curative treatment

3 weeks ago | 2minutemedicine.com | Neel Mistry

1. 5-year breast cancer-specific survival was comparable between annual and less frequent mammography groups. 2. Less-frequent mammographic surveillance showed a similar recurrence-free interval. Evidence Rating Level: 1 (Excellent)Study Rundown: Breast cancer surveillance guidelines vary worldwide, with uncertainty regarding the necessity of annual mammograms for survivors.
2 Minute Medicine Rewind March 31, 2025

3 weeks ago | 2minutemedicine.com | Jayden Berdugo |Alex Chan

Suicide risk and living alone with depression or anxiety 1. In this cohort of adults living in South Korea, individuals living alone with anxiety and depression were associated with the highest risk of suicide. Evidence Rating Level: 1 (Excellent) Suicide is responsible for over half a million deaths worldwide every year and is a global health emergency. Globally, suicide rates vary, however, they have been the highest in South Korea, with rates reaching 24.1 suicides per 100,000 individuals.
Higher nicotine consumption observed among youth with attention-deficit hyperactivity disorder

4 weeks ago | 2minutemedicine.com | Jayden Berdugo |Alex Chan

1. This cohort of United States youths with asymptomatic attention-deficit hyperactivity disorder (ADHD), did not have statistically significant differences in their odds of starting nicotine or tobacco products compared with the control group. 2. The youths with more ADHD symptoms had a greater likelihood of starting nicotine or tobacco products compared to the control group. Evidence Rating Level: 2 (Good) Study Rundown: Tobacco use is the leading cause of preventable death worldwide.
Characterization of increased aspiration pneumonia risk in patients with stroke

4 weeks ago | 2minutemedicine.com | Paary Balakumar |Alex Chan

1. Aspiration pneumonia in post-stroke patients showed significantly increased 90-day mortality, longer hospital stays, and more cardiovascular events at one year 2. Stroke patients admitted to the medicine ward had increased pneumonia risk compared to stroke unit admission Evidence Rating Level: 2 (Good) This retrospective cohort study analyzed the impact of stroke severity on the risk of aspiration pneumonia in patients admitted to a stroke unit versus a general medical ward.
Music listening may be an effective adjunct for pain control

1 month ago | 2minutemedicine.com | Paary Balakumar |Alex Chan

1. Using music for pain relief is highly valued by participants but requires a proactive and personalized approach 2.
2 Minute Medicine Rewind March 24, 2025

1 month ago | 2minutemedicine.com | Paary Balakumar |Alex Chan

Effects of occupational therapy synchronized with dual transcranial direct current stimulation on upper limb function and electroencephalography power in subacute stroke patients: A randomized, double-blind, controlled study1.
Benzodiazepine initiation post stroke associated with increased falls risk

1 month ago | 2minutemedicine.com | Paary Balakumar |Alex Chan

1. In older adults post-acute ischemic stroke, benzodiazepine initiation was associated with an increase in 10-day fall and fall-related injury risk. 2. The highest risk increase was seen in patients aged 65-74 years old and those with minor acute ischemic stroke. Evidence Rating Level: 2 (Good) This study examined the association between benzodiazepine initiation and the risk of falls or fall-related injuries (FRIs) in older adults following acute ischemic stroke (AIS).