Boston Children's Hospital (Answers)

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A druggable target for AML: cell-surface RNA-binding proteins

1 day ago | answers.childrenshospital.org | Nancy Fliesler

In 2021, research led by Ryan Flynn, MD, PhD, and his mentor, Nobel laureate Carolyn Bertozzi, PhD, opened a new chapter in biology, characterizing a new kind of player on the cell surface: glycoRNAs. Extending this discovery recently in Cell, Flynn and colleagues showed that glycoRNAs form highly organized clusters with RNA-binding proteins on the cell surface. These clusters appear to regulate communication between cells and their environment.
Jackie’s dreams of playing professional soccer back on track after ACL surgery

2 days ago | answers.childrenshospital.org | Joanne Barker

From her dorm in Newcastle, England, Jackie Zapata can hear fans roaring in the soccer stadium a few blocks away. Soccer is a major pastime in her adopted home. “The city gets amped up anytime there’s a game,” she says. “It’s a huge part of the culture here.” This enthusiasm makes Newcastle a good place for 21-year-old Jackie to live, study, and train. Jackie was 10 when, inspired by a flyer for the 2014 World Cup, she set her sights on playing professional soccer.
Pressure-volume loops for heart surgery

1 week ago | answers.childrenshospital.org | Albert McKeon

When Mikolaj “Mickey” Karski’s family traveled from Poland to Boston to get him heart care, they weren’t thinking about pressure-volume (PV) loops. His parents simply wanted him to receive treatment for a complex condition that he couldn’t get back home. Little did they know the mathematical computational power of those PV loops would play a large role in doing just that.
No limitations: How Flora found answers for MOG antibody disease

1 week ago | answers.childrenshospital.org | Jessica Cerretani

Flora Ringler’s fifth birthday didn’t turn out as she had hoped. She and her family were vacationing in New Hampshire last year when she started feeling tired. But she wasn’t just worn out from celebrating: She also developed a bad headache and started throwing up. Concerned, her mom, Maureen, contacted a pediatrician, who thought she might have a virus. A week passed and Flora’s symptoms hadn’t cleared up. Blood tests came back positive for Lyme disease and she started taking antibiotics.
Future outcomes of childhood cancer survivors

1 week ago | answers.childrenshospital.org | Nancy Fliesler

Children are much more likely to survive cancer today than 50 years ago. Unfortunately, as adults, many of them develop cardiovascular disease, secondary cancers, or both, believed to result from the toxic effects of chemotherapy and radiation. But the full risk picture for survivors hasn’t been clear. “Patients want to know how long they’ll live once they’ve been treated for cancer.
Genetics transforms care for severe diarrhea: Asa's story

1 week ago | answers.childrenshospital.org | Nancy Fliesler

Asa Cibelli feels like he’s been reborn. The straight-A middle schooler plays basketball and football, does jiu jitsu, is learning guitar, and can solve a Rubik’s cube in 40 seconds flat. But he once wondered if he’d ever feel better. From birth, Asa experienced chronic abdominal pain and severe diarrhea. The many doctors he saw at different medical centers in his home state of California couldn’t figure out why. “We went from doctor to doctor to department to department,” says his mother Katie.
Genetic causes emerge for congenital diarrhea and enteropathy

1 week ago | answers.childrenshospital.org | Nancy Fliesler

Congenital diarrheas and enteropathies are rare and devastating for infants and children. Treatments have consisted mainly of fluid and nutritional management. But in recent years, targeted dietary and drug therapies have emerged based on genetic discoveries. Now, research led by Boston Children’s Hospital, The Hospital for Sick Children in Toronto, and UCLA takes a major step toward genetically guided care for these conditions.
What orthopedic trauma surgeons wish more parents knew about lawnmower injuries

2 weeks ago | answers.childrenshospital.org | Joanne Barker

Summer is full of delights: lemonade, ice cream, and fresh-cut grass to name a few. Unfortunately, the warmer months can also come with a type of injury that takes many families by surprise. Mowing the lawn may seem perfectly normal and safe. However, the blades that cut the grass can also do serious damage to people, many of them children. In fact, as many as 17,000 children suffer lawnmower injuries each year.
The thalamus: A potential target for neurodevelopmental disorders

2 weeks ago | answers.childrenshospital.org | Nancy Fliesler

Years ago, as a neurology resident, Chinfei Chen, MD, PhD, cared for a 20-year-old woman who had experienced a very small stroke, affecting only the thalamus. “It was so tiny that she wouldn’t have noticed any symptoms had the stroke been in any other area of the brain,” says Chen, who is now an investigator at the F.M. Kirby Neurobiology Center at Boston Children’s Hospital. “But she lost her ability to form new memories.
Using her voice: After tracheomalacia treatment, Claire keeps her eye on the ball

3 weeks ago | answers.childrenshospital.org | Jessica Cerretani

Claire Kantany is only 10, but she knows what she wants to do when she grows up — in fact, she’s already doing it. Combining an interest in acting with her family’s love of football, she has her mind set on a career in sportscasting. Not only is she reporting on local games from the sidelines, but she’s also caught the attention of her idol, NFL sportscaster Erin Andrews. But it wasn’t too long ago that Claire struggled to breathe, especially when she was active.