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Articles

Oral Agent Shows Weight, A1c Drops

1 week ago | conexiant.com | Bhanvi Satija |Manas Mishra

Eli Lilly reported that its investigational oral agent, orforglipron, achieved body weight reductions of up to 7.9% and lowered HbA1c in adults with type 2 diabetes in a phase III trial. The once-daily GLP-1 receptor agonist was associated with mean weight loss of 4.7% at 3 mg, 6.1% at 12 mg, and 7.9% at 36 mg after 40 weeks. Participants receiving placebo lost 1.6%. HbA1c levels decreased by a mean of 1.3% to 1.6% across treatment groups.
RSV Vaccine Access Under CDC Review

1 week ago | conexiant.com | Sneha K |Mariam Sunny

The CDC’s vaccine advisory committee is expected to vote on expanding access to RSV vaccines during the second session of its meeting. Guidelines from the Advisory Committee on Immunization Practices (ACIP) inform clinician decision-making and influence insurance coverage determinations in the U.S.Three RSV vaccines have been approved by the U.S. Food and Drug Administration: GSK’s Arexvy, Moderna’s mRESVIA, and Pfizer’s Abrysvo.
FDA Clears Tablet for Cholestatic Pruritus

1 week ago | conexiant.com | Kathryn Wighton

A new tablet formulation of maralixibat could offer an alternative to the oral solution, with once-daily dosing among patients with Alagille syndrome and twice-daily dosing among those with progressive familial intrahepatic cholestasis. The formulation is intended to treat those who may benefit from a solid-dose option.
New Self-Injection Option for gMG, CIDP

2 weeks ago | conexiant.com | Kathryn Wighton

The FDA has approved a prefilled syringe formulation of VYVGART Hytrulo (efgartigimod alfa and hyaluronidase-qvfc) for subcutaneous self-injection in adult patients with generalized myasthenia gravis who are anti–acetylcholine receptor antibody positive, as well as in adult patients with chronic inflammatory demyelinating polyneuropathy. This formulation offers an additional administration option alongside intravenous infusion and subcutaneous injection via vial.
FDA Clears Longest Lasting CGM

2 weeks ago | conexiant.com | Kathryn Wighton

The U.S. Food and Drug Administration has cleared a novel continuous glucose monitoring system known as Dexcom G7 15 Day for use in patients aged 18 years and older with diabetes. The updated continuous glucose monitoring (CGM) system offers up to 15.5 days of wear, making it the longest lasting wearable CGM system currently cleared in the United States.
FDA Clears Stapler for Single-Port Surgery

2 weeks ago | conexiant.com | Kathryn Wighton

Intuitive's SP SureForm 45 stapler was cleared by the U.S. Food and Drug Administration for use with the da Vinci SP surgical system in thoracic, colorectal, and urologic procedures. The clearance introduces the first stapler specifically designed for single-port robotic-assisted surgery. The SP SureForm 45 incorporates SmartFire technology, which continuously monitors tissue compression prior to and during staple firing, according to a press release from Intuitive.
Food Additive Mixtures May Be Linked to Diabetes Risk

2 weeks ago | conexiant.com | Kerri Miller

In a large-scale prospective cohort study, researchers identified two frequently consumed food additive mixtures that may be associated with an elevated risk of type 2 diabetes, independent of the nutritional quality of the diet. The study, conducted within the French NutriNet-Santé cohort, followed 108,643 participants over a mean period of 7.7 years and identified 1,131 incident cases of type 2 diabetes.
Dual Immunotherapy Approved for Advanced CRC

2 weeks ago | conexiant.com | Kathryn Wighton

Patients with microsatellite instability–high or mismatch repair–deficient colorectal cancer treated with nivolumab plus ipilimumab had a median progression-free survival that was not reached, compared with 5.8 months for patients treated with chemotherapy, according to a recent press release.
Oral Microbiome Linked to Chronic Pain in Women

2 weeks ago | conexiant.com | Kerri Miller

A new study has identified significant associations between poor oral health, oral microbiome composition, and various pain presentations in women with central sensitization disorders, including migraine, fibromyalgia, and functional abdominal pain.
Mediterranean Diet, Exercise Boost Bone Health in Older Women

2 weeks ago | conexiant.com | Kerri Miller

A 3-year randomized clinical trial has found that a weight-loss lifestyle intervention combining an energy-reduced Mediterranean diet with physical activity may produce beneficial effects on bone mineral density (BMD), particularly at the lumbar level, in older women with metabolic syndrome. The findings, published in JAMA Network Open, suggested that such interventions may help preserve bone health during intentional weight loss in populations at risk for osteoporotic fractures.