PharmaExcipients

PharmaExcipients is a distinctive online platform that provides information and facilitates discussions on key subjects concerning pharmaceutical excipients, which are the inactive ingredients used in medications.

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World Antimicrobial Resistance Awareness Week 2024

Oct 26, 2024 | pharmaexcipients.com | Theresa Hartmann

World Antimicrobial Resistance Awareness Week takes place every year from 18 to 24 November and will be held for the 10th time in 2024. Aim is to raise awareness about the dangers of antimicrobial resistance (AMR) and promoting best practices to prevent the spread of drug-resistant infections. It engages the general public, healthcare professionals, and policymakers in efforts to combat AMR. In 2024 the theme for the global campaign is “Educate. Advocate.
Breast Cancer Awareness Month 2024

Oct 5, 2024 | pharmaexcipients.com | Theresa Hartmann

Breast Cancer Awareness Month is an international health campaign that takes place every October. The Breast Cancer Awareness Month aims to raise awareness about breast cancer, encourage early detection, and support research and treatment. The initiative was started in 1985 as a partnership between the American Cancer Society and the pharmaceutical division of Imperial Chemical Industries (now part of AstraZeneca).
World AIDS Day 2024

Sep 28, 2024 | pharmaexcipients.com | Theresa Hartmann

World AIDS Day takes place every year on 1st December and will be held for the 36th time in 2024. Aim is to raise awareness of the AIDS pandemic. It serves as a time to honor those who have passed, educate about the disease’s ongoing effects, and unite in the fight to end the harmful stigma surrounding HIV/AIDS. The World AIDS Conference theme was “Putting people first”. The World AIDS Conference was held for the 25th time in July 2024.
Amorphous Polymer–Phospholipid Solid Dispersions for the Co-Delivery of Curcumin and Piperine Prepared via Hot-Melt Extrusion - Pharma Excipients

Aug 31, 2024 | pharmaexcipients.com | Theresa Hartmann

Curcumin and piperine are plant compounds known for their health-promoting properties, but their use in the prevention or treatment of various diseases is limited by their poor solubility. To overcome this drawback, the curcumin–piperine amorphous polymer–phospholipid dispersions were prepared by hot melt extrusion technology. X-ray powder diffraction indicated the formation of amorphous systems.
Evaluation of the application of polyethylene glycol 8000 as a plasticizer for the development of solid dispersions based on ellagic acid and Eudragit® EPO using hot melt extrusion - Pharma Excipients

Aug 19, 2024 | pharmaexcipients.com | Theresa Hartmann

Solid dispersion formation by hot melt extrusion (HME) is a widely used formulation strategy to improve the solubility and bioavailability of poorly water-soluble drugs. Despite this, they are limited by various factors such as drug-excipient miscibility, poor stability, limited drug loading and extrudability of physical drug-excipient mixtures.
Towards the prediction of barrel fill level in twin-screw wet granulation

Aug 18, 2024 | pharmaexcipients.com | Theresa Hartmann

The barrel fill level is defined as the fraction of the free available volume for a given screw configuration that is occupied by the wet material and is an interplay of the material throughput, screw speed, screw setup, barrel length of the twin-screw granulator used and the properties of the starting material. The fill level has a major impact on mixing and densification of the wetted mass and thus on the granules produced. It influences the twin-screw granulation process accordingly.
Advances in active targeting of ligand-directed polymeric nanomicelles via exploiting overexpressed cellular receptors for precise nanomedicine

Aug 17, 2024 | pharmaexcipients.com | Theresa Hartmann

Many of the utilized drugs which already exist in the pharmaceutical sector are hydrophobic in nature. These drugs are characterized by being poorly absorbed and difficult to formulate in aqueous environments with low bioavailability, which could result in consuming high and frequent doses in order to fulfil the required therapeutic effect. As a result, there is a decisive demand to find modern alternatives to overcome all these drawbacks.
Characterization of Prototype Gummy Formulations Provides Insight into Setting Quality Standards

Aug 17, 2024 | pharmaexcipients.com | Theresa Hartmann

Gummy formulations are considered suitable alternatives to traditional oral dosage forms like tablets and capsules due to their merits that include chewability, softness/flexibility, improved drug release, administration without water, appealing organoleptic properties, better patient compliance, easy preparation and usefulness for persons of different ages (e.g. children).
An experimental study on flow behaviour in suction filling of pharmaceutical powders

Aug 16, 2024 | pharmaexcipients.com | Theresa Hartmann

Die filling is a crucial step in the pharmaceutical tablet manufacturing process. For industrial-scale production using rotary presses, suction filling is typically employed due to its significant efficiency advantages over gravity filling. Despite its widespread use, our understanding of the suction filling process remains limited.
A continuous micro-feeder for cohesive pharmaceutical materials

Aug 16, 2024 | pharmaexcipients.com | Theresa Hartmann

Over the past decade, continuous manufacturing has garnered significant attention in the pharmaceutical industry. Still, numerous continuous unit operations need developments, such as powder blending and feeding at low and high throughputs. Especially the continuous and consistent feeding of solid drug substances and excipients at low feed rates remains challenging. This study demonstrates a micro-feeder capable of feeding poorly-flowing pharmaceutical powders at low feed rates.