Review of Ophthalmology

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The Evolving Landscape of Dry-eye Therapeutics

2 weeks ago | reviewofophthalmology.com | Catlin Nalley

Dry-eye disease is one of the most commonly encountered yet persistently challenging conditions in ophthalmology. Characterized by ocular surface inflammation, tear film instability, and a spectrum of often debilitating symptoms, DED affects millions worldwide. And despite a growing list of available therapies, many patients continue to struggle with incomplete or inconsistent relief.
Mastering Optic Capture

1 month ago | reviewofophthalmology.com | Liz Hunter

Figure 1. Optic capture of a three-piece intraocular lens. Note the ellipsoid shape of the anterior capsular opening behind the optic of the lens with the haptics in the ciliary sulcus. Photo: Kourtney H. Houser, MD. Cataract patients with evidence of zonular weakness whether clinically or intraoperatively may benefit from a three-piece IOL in the sulcus with the primary optic capture technique. It’s useful especially in cases of posterior capsule rupture, providing added stability.
A Look Down the Premium IOL Pipeline

1 month ago | reviewofophthalmology.com | Michelle Stephenson

Premium IOLs have improved patients’ ability to see clearly at all distances, and patient satisfaction with these lenses is high. Several new premium IOLs currently under study have shown promise and may soon be added to surgeons’ armamentarium. Figure 1. The Galaxy IOL by Rayner was designed by AI.
Investigating IOL Complaints

2 months ago | reviewofophthalmology.com | Liz Hunter

Ocular surface issues are often exacerbated by cataract surgery, leading to patient dissatisfaction. Here, a patient presented in the clinic with complaints of blurred vision after cataract surgery with a multifocal IOL. Fluorescein staining revealed signs of anterior basement membrane dystrophy.1 Photo: Allister Gibbons, MD. The daily experience of a refractive cataract surgeon likely proves that the better the IOLs get, the higher patient expectations become.
Alternatives to the Yamane Technique

2 months ago | reviewofophthalmology.com | Christine Leonard

In the Yamane technique, the IOL haptics are inserted into the lumen of a needle and externalized through sclerotomies before flange creation. Photo: Uday Devgan, MD. Eyes with zonular loss and inadequate capsular support often require secondary intraocular lens fixation to restore vision.
Refractive CXL: An Update

2 months ago | reviewofophthalmology.com | Liz Hunter

Corneal collagen cross-linking has become the mainstay of treating keratoconus and corneal ectasia. The observed corneal flattening that takes place in eyes treated with CXL fostered theories about its utility as a primary refractive procedure, and while subsequent studies have seemingly supported this idea, it hasn’t been widely adopted. We spoke with A.
April 2025 Wills Eye Resident Case Series

2 months ago | reviewofophthalmology.com | Iniya Adhan |Karen Lee |Barry Wasserman

Presentation Figure 1. (A) Fusion of the lateral 30 percent of the upper and lower lids in the right eye. (B) Three extensile connective tissue bands measuring approximately 1 mm in length and 3 to 4 mm in width located medial, lateral and near the lateral canthus of the left eyelids. An 8-day-old boy presented to Wills Eye’s pediatric ophthalmology clinic with inability to open the left eye and partial ability to open the right eye.
Navigating Unplanned Anterior Vitrectomies

Mar 21, 2025 | reviewofophthalmology.com | Liz Hunter

Every cataract surgeon knows to expect the unexpected, and that includes inadvertently rupturing the posterior capsule. This complication can throw a wrench into an otherwise routine day in the OR, but if they remain calm and remember the proper steps for performing an anterior vitrectomy, cataract surgeons can manage the case efficiently and focus on their next patient.
Current Therapies for PVR

Mar 21, 2025 | reviewofophthalmology.com | Michelle Stephenson

Proliferative vitreoretinopathy is the main cause of failure after retinal detachment surgery. “There is going to be some proliferation in all cases of retinal detachment. It’s a matter of whether it’s so excessive that it causes enough harm to frustrate the success of the surgery,” says William Smiddy, MD, in practice at Bascom Palmer Eye Institute. When PVR does occur, it has traditionally been treated surgically. According to Jennifer Lim, MD, in practice at the University of Illinois at Chicago.
Dealing with Post-Cataract Inflammation

Mar 21, 2025 | reviewofophthalmology.com | Liz Hunter

Advancements in instrument cleaning, draping and the use of intracameral antibiotics have all contributed to the remarkably low risk of endophthalmitis following cataract surgery—which one 2019 study estimated to be 1.36 incidents per 1,000 surgeries.1 Despite its rarity, cataract surgeons should remain vigilant about its characteristics, many of which can resemble other forms of inflammation—namely toxic anterior segment syndrome.