The Journal of Allergy & Clinical Immunology

The Journal of Allergy and Clinical Immunology (JACI) is a medical journal focused on allergy and immunology, and it operates under an open access model. It serves as one of the two official journals for the American Academy of Allergy, Asthma, and Immunology. Initially launched in 1929 as the Journal of Allergy, it was renamed in 1971 to reflect a broader understanding of the term "allergy" among medical professionals. Since its beginning, the journal has been published by Mosby. Currently, JACI is released on a monthly basis, whereas its earlier version was published every two months.

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English

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#173986

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#101754

Health/Health Conditions and Concerns

#228

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Articles

Cohort-driven variant burden analysis and pathogenicity identification in monogenic autoinflammatory disorders

Apr 6, 2023 | jacionline.org | Xiang Chen
News beyond our pages

Apr 4, 2023 | jacionline.org | Marc E. Rothenberg |Jean Bousquet
News beyond our pages

Apr 4, 2023 | jacionline.org | Marc E. Rothenberg |Jean Bousquet

Despite its universality, the molecular mechanisms underlying the aging process remain poorly understood. Liu et al (Cell 2023;186:287-304.e26; https://doi.org/10.1016/j.cell.2022.12.017) uncovered a positive feedback loop between the activation of dormant endogenous retroviruses and aging. More specifically, cellular senescence induced the reactivation and accumulation of the endogenous retrovirus HERVK.
Neighborhood Environmental Vulnerability and Pediatric Asthma Morbidity in US Metropolitan Areas

Mar 27, 2023 | jacionline.org | Sneha Kannoth |Sarah Chung |Kelvin D. Tamakloe |Sandra Albrecht

Abstract Background Research suggests demographic, economic, residential, and health-related factors influence vulnerability to environmental exposures. Greater environmental vulnerability may exacerbate environmentally-related health outcomes. We developed a neighborhood environmental vulnerability index (NEVI) to operationalize environmental vulnerability on a neighborhood-level.
Neighborhood Environmental Vulnerability and Pediatric Asthma Morbidity in US Metropolitan Areas

Mar 27, 2023 | jacionline.org | Sarah Chung
The importance of Studying Genetic Ancestry in Eosinophilic Esophagitis

Mar 22, 2023 | jacionline.org | Katie M. Marker |Rasika A. Mathias |Johns Hopkins |Christopher R. Gignoux

Eosinophilic esophagitis (EoE), a chronic allergic inflammatory disease, is linked to multiple genetic risk factors, but studies have focused on populations of European ancestry. Few studies have assessed Black or African American (AA) populations for loci involved in EoE susceptibility.
Autoimmune manifestations in VEXAS: Opportunities for integration and pitfalls to interpretation

Mar 20, 2023 | jacionline.org | Alessandro Bruno |Vita-Salute San Raffaele |Carmelo Gurnari

This year’s best in hematology diagnosis: a new disease is discovered. Hematologist. 2022; 19Beck D.B. Ferrada M.A. Sikora K.A. Ombrello A.K. Collins J.C. Pei W. et al. Somatic mutations in UBA1 and severe adult-onset autoinflammatory disease. N Engl J Med. 2020; 383: 2628-2638Barba T. Jamilloux Y. Durel C.A. Bourbon E. Mestrallet F. Sujobert P. et al. VEXAS syndrome in a woman. Rheumatology (Oxford). 2021; 60: E402-E403Tsuchida N. Kunishita Y. Uchiyama Y. Kirino Y. Enaka M. Yamaguchi Y. et al.
Stratification of asthma by lipidomic profiling of induced sputum supernatant

Mar 11, 2023 | jacionline.org | James Schofield
Reply

Mar 3, 2023 | jacionline.org | Vamsi P. Guntur |Camille Moore |Laurie A. Manka

To the Editor:We read with enthusiasm the correspondence by Nomura et al1Nomura N. Matsumoto H. Sunadome H. Oguma T. Hirai T. Importance of mucus burden and mucociliary impairment in asthma. in reference to our original article “Refractory neutrophilic asthma and ciliary genes.”2Guntur V.P. Manka L.A. Moore C.M. Wynn E. Vladar E.K. Alam R. et al. Refractory neutrophilic asthma and ciliary genes.
Reply

Mar 3, 2023 | jacionline.org | Camille Moore