A. J. Shapiro

Oct 8, 2024 | onlinecjc.ca | S. Pulente |C. McMaster |N. Trzaskalski |S. Gupta |M. Lewandowska |A. J. Shapiro | +2 more

Heart failure (HF) develops when pathological stresses chronically persist, often after a cardiovascular event. A lesser-known HF risk factor is a deficiency of a circulating protein called plasminogen activator inhibitor-1 (SERPINE-1/PAI-1). Specifically, individuals carrying a loss-of-function mutation in PAI-1 exhibit an increased cardiac fibrosis (CF) burden which can lead to HF.