Aayush Grover

Jan 15, 2025 | biorxiv.org | Aayush Grover |Lin Zhang |Simeon Häfliger |Minjia Wang

AbstractInteractions between enhancers and gene promoters provide insights into gene regulation. Experimental techniques, including Hi-C, that map these enhancer-promoter interactions (EPIs), have high costs and labor requirements, which limits their use. Therefore, in silico methods have been developed to predict EPIs computationally, but there are challenges with the generalizability and accuracy of existing methods.

Nov 23, 2024 | biorxiv.org | Aayush Grover |Lin Zhang |Minjia Wang |Simeon Häfliger

AbstractChromatin interactions between cis-regulatory elements (CREs) and specific gene promoters offer insights into the mechanisms of gene activation and repression. This knowledge is crucial for evaluating the effects of non-coding variants and chromatin alterations in cell differentiation or disease. Experimental techniques Hi-C and single-cell Hi-C provide information on CRE-promoter interactions, but the high costs and labor requirements limit their widespread use.