Abderhman Abuhashem

Oct 12, 2024 | biorxiv.org | Alexandra Chivu |Abderhman Abuhashem |Michelle M. Leger |Brent A Basso

AbstractPromoter-proximal pausing of RNA polymerase II (Pol II) is a key regulatory step during transcription. Despite the central role of pausing in gene regulation, we do not understand the evolutionary processes that led to the emergence of Pol II pausing or its transition to a rate-limiting step actively controlled by transcription factors. Here we analyzed transcription in species across the tree of life.