Abigail Ramsøe

Oct 21, 2024 | onlinelibrary.wiley.com | Lei Zhao |Rasmus Henriksen |Abigail Ramsøe |Rasmus Nielsen

1 Introduction Ancient DNA (aDNA) refers to the preserved genetic material of ancient organisms. Analysing aDNA has proven to be an essential mean for researchers to study the past. It has, for example, aided a deeper understanding of ancestral population history (Allentoft, Sikora, Fischer, et al. 2024; Allentoft, Sikora, Refoyo-Martínez, et al. 2024) and the dynamics of ancient ecosystems (Kjær et al. 2022; Fernandez-Guerra et al. 2023).

Nov 6, 2023 | biorxiv.org | Lei Zhao |Rasmus Henriksen |Abigail Ramsøe |Rasmus Nielsen

AbstractMotivation: One essential initial step in the analysis of ancient DNA is to authenticate its ancientness to ensure reliable conclusions. That is, meticulously assessing whether next-generation sequencing reads exhibit ancient characteristics, with a particular focus on the postmortem damage (PMD) signal induced by cytosine deamination in the fragments termini.