Abigail Shea

2 weeks ago | biorxiv.org | Cecilia Roux |Sian Hamer |Abigail Shea |Emilia Annabeth Chen

AbstractNeuroblastoma, like many aggressive cancers, exhibits phenotypic heterogeneity, contributing to therapy resistance and disease progression. However, direct evidence of how phenotypic plasticity influences tumour evolution remains limited. Using a multi-resolution quantitative approach, we define the principles, types, and dynamics of plasticity in neuroblastoma at unprecedented resolution.