Abimbola Feyisara Adedeji-Olulana

Oct 31, 2024 | science.org | Jerika J. Barron |Zhenyu Wang |Roberto Arbore |Abimbola Feyisara Adedeji-Olulana

Editor’s summaryThe β-lactam class of antibiotics are the most prescribed drugs worldwide. These molecules kill bacteria by inactivating penicillin-binding proteins (PBPs), a group of enzymes responsible for cross-linking bacterial cell wall peptidoglycan. Methicillin-resistant Staphylococcus aureus (MRSA) has acquired resistance to β-lactams through the mecA gene encoding PBP2a, a non-native PBP with low affinity to β-lactams. Adedeji-Olulana et al.