Addison J. Lana

Nov 14, 2024 | biorxiv.org | Christopher Balak |Johannes C.M. Schlachetzki |Addison J. Lana |Elizabeth West

AbstractLysosomal dysfunction is causally linked to neurodegeneration in many lysosomal storage disorders (LSDs) and is associated with various age-related neurodegenerative diseases, but there is limited understanding of the mechanisms by which altered lysosomal function leads to changes in gene expression that drive pathogenic cellular phenotypes.