Adil Muneer

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Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer’s disease-associated proteopathology - Nature Communications

1 month ago | nature.com | Ryan Sheehy |Adil Muneer |Yan Xiong |John A. Wrobel |Feng Zhang |Kwang-Su Park | +11 more

AbstractCurrent Aβ-targeting therapeutics for Alzheimer’s disease (AD) only slow cognitive decline due to poor understanding of AD pathogenesis. Here we describe a mechanism of AD pathogenesis in which the histone methyltransferase G9a noncanonically regulates translation of hippocampal proteins associated with AD pathology.

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