Aedín C. Culhane

May 3, 2024 | nature.com | Michela Riba |Cinzia Sala |Aedín C. Culhane |Åsmund Flobak |Attila Patócs |Kjetil Boye | +19 more

Defining minimal standards for data collection is key to creating interoperative, searchable genomic and clinical databases. We highlight here the 1+Million Genomes Minimal Dataset for Cancer, encompassing 140 items in 8 domains to foster the collection of cancer data, inform transnational cooperation and advance precision cancer medicine.

Oct 10, 2023 | biorxiv.org | Michela Riba |Aedín C. Culhane |Åsmund Flobak |Cinzia Sala

AbstractFor a real impact on healthcare, precision cancer medicine requires accessibility and interoperability of clinical and genomic data across centres and countries. Due to the heterogeneous digitization in Europe and worldwide, the definition of models for standardised data collection and usability becomes mandatory if countries want to work together on this mission.

May 26, 2023 | nature.com | Benjamin Barwick |Vikas Gupta |Yiguo Hu |Jordan G Bryan |Andrew J. Aguirre |Benjamin Ebert | +12 more

AbstractClinical progress in multiple myeloma (MM), an incurable plasma cell (PC) neoplasia, has been driven by therapies that have limited applications beyond MM/PC neoplasias and do not target specific oncogenic mutations in MM. Instead, these agents target pathways critical for PC biology yet largely dispensable for malignant or normal cells of most other lineages.