Ahmad Ozair

Dec 9, 2024 | nature.com | Ahmad Ozair |Nicholas Mikolajewicz |Stuart A Grossman |Arjun Sahgal |Emilie Le Rhun |Michael Weller | +12 more

AbstractLeptomeningeal metastatic disease (LMD), encompassing entities of ‘meningeal carcinomatosis’, neoplastic meningitis’ and ‘leukaemic/lymphomatous meningitis’, arises secondary to the metastatic dissemination of cancer cells from extracranial and certain intracranial malignancies into the leptomeninges and cerebrospinal fluid.

Jul 1, 2024 | cell.com | Manmeet Ahluwalia |Ahmad Ozair |Johns Hopkins

Highlights • Multicenter, phase 1 trial of oral terameprocol for recurrent high-grade glioma • Drug well tolerated in 3 + 3 dose-escalation design, but bioavailability was poor (∼2%) • Higher oral doses in patients not associated with increased systemic exposure • Trials investigating sustained systemic levels of transcription inhibitors are needed Summary Recurrent high-grade gliomas (rHGGs) have a dismal prognosis, where the maximum tolerated dose (MTD) of IV terameprocol (5 days/month), a...

Mar 5, 2024 | community.lww.com | Ahmad Ozair

Ahmad Ozair is a physician-researcher from India and one of 14 Sommer Scholars worldwide in the 11-month MPH program at Johns Hopkins Bloomberg School of Public Health (>100,000 USD of scholarship). He is also an incoming Clarendon Scholar for Oxford's MSc in Evidence-Based Healthcare (EBHC) course (Clarendon is awarded to the top 1% of graduate students at the University of Oxford). Ahmad was previously a postdoctoral research fellow in neuro-oncology at Miami Cancer Institute.

Jan 15, 2024 | informahealthcare.com | Ahmad Ozair |Simon Lo

View correction statement: PFS = Progression free survival JAK = Janus Kinase MTD = Maximum Tolerated Dose ORR = Objective Response Rate AE = Adverse Events DFS = Disease Free Survival DLT = Dose Limiting Toxicity MTX = Methotrexate NM = Neoplastic meningitis LM = Leptomeningeal metastasis BC = Breast cancer CNS = Central Nervous System CSF = Cerebrospinal fluid HDMTX = High-dose methotrexate OS = Overall survival IT = Intrathecal chemotherapy RT = Radiation therapy SC = Systemic chemotherapy...

Dec 26, 2023 | tandfonline.com | Ahmad Ozair |Simon Lo

ABSTRACTIntroduction Neoplastic meningitis (NM), also known as leptomeningeal carcinomatosis, is characterized by the infiltration of tumor cells into the meninges, and poses a significant therapeutic challenge owing to its aggressive nature and limited treatment options. Breast cancer is a common cause of NM among solid tumors, further highlighting the urgent need to explore effective therapeutic strategies.