Akari Suzuki

Nov 1, 2024 | biorxiv.org | Masaru Koido |Akari Suzuki |Kohei Tomizuka |Soichiro Yoshino

AbstractOpen chromatin regions (OCRs) provide genome-wide DNA elements in a cell-type-specific manner at high resolution but do not always mark active regulatory regions, hampering pinpointing causal functional variants in genetic association studies. Here, we developed a new scoring system, CAMBUS (Chromatin Accessibility Mutation Burden Score), to find active and constraint OCRs via machine-learning predictions of OCRs from surrounding DNA sequences.

Jul 4, 2024 | science.org | Akiko Oguchi |Aaron Weimann |Bojana Müller-Durovic |Akari Suzuki

Editor’s summaryCurrently, 3′ single-cell RNA sequencing is widely used as a tool for single-cell gene expression analysis. By leveraging a distinctive “cap signature” derived from the 5′-end cap, Oguchi et al. introduced a technique to investigate the precise position of the RNA 5′-ends in single cells, enabling simultaneous profiling of gene expression and enhancer activity.