Akihiro Otomo

Nov 21, 2024 | nature.com | Kano Suzuki |Akihiro Otomo |Satoshi Yasuda |Naruhiko Adachi |So Iwata |Toshiya Senda | +2 more

AbstractVancomycin-resistant Enterococcus faecium (VRE) is a major cause of nosocomial infections, particularly endocarditis and sepsis. With the diminishing effectiveness of antibiotics against VRE, new antimicrobial agents are urgently needed. Our previous research demonstrated the crucial role of Na+-transporting V-ATPase in Enterococcus hirae for growth under alkaline conditions. In this study, we identified a compound, V-161, from 70,600 compounds, which markedly inhibits E.