Akos Gerencser

Jan 10, 2024 | nature.com | Kenneth Wilson |Sudipta Bar |Eric B. Dammer |Joanna Bons |Grace Qi |Akos Gerencser | +6 more

AbstractDietary restriction (DR) delays aging, but the mechanism remains unclear. We identified polymorphisms in mtd, the fly homolog of OXR1, which influenced lifespan and mtd expression in response to DR. Knockdown in adulthood inhibited DR-mediated lifespan extension in female flies. We found that mtd/OXR1 expression declines with age and it interacts with the retromer, which regulates trafficking of proteins and lipids.