Alden K Leung

Dec 2, 2024 | biorxiv.org | You Chen |Sagar Shah |Alden K Leung |Mauricio I. Paramo

AbstractDivergent transcription is a critical marker of active transcriptional regulatory elements (TREs), including enhancers and promoters, in mammals. However, distal elements with unidirectional transcriptional patterns are often overlooked, leaving their identity and function poorly understood. Here, we performed a systematic comparison between divergent and unidirectional elements, revealing their distinct architectural and functional features.