Alex Zelter

Apr 3, 2024 | biorxiv.org | Juan Jesus Vicente |Michael Wagenbach |Justin Decarreau |Alex Zelter

AbstractCentrosomes are the principal microtubule-organizing centers of the cell and play an essential role in mitotic spindle function. Centrosome biogenesis is achieved by strict control of protein acquisition and phosphorylation prior to mitosis. Defects in this process promote fragmentation of pericentriolar material culminating in multipolar spindles and chromosome missegregation.