Alexander Gabel

Oct 3, 2023 | cell.com | Nora Schmidt |Alexander Gabel |Sebastian Zieliński |Caleb A Lareau

Highlights•SND1 is required for nascent SARS-CoV-2 RNA synthesis early during infection•SND1 directly interacts with NSP9 and both proteins bind negative-sense viral RNA•NSP9 is covalently linked to viral RNA at initiation sites, indicating protein priming•SND1 modulates the covalent linkage of NSP9 to positive- and negative-sense viral RNASummaryRegulation of viral RNA biogenesis is fundamental to productive SARS-CoV-2 infection.