Alexander J. Dear

May 10, 2024 | pubs.rsc.org | Jiapeng Wei |Lensfield Road |Georg Meisl |Alexander J. Dear

Kinetic models reveal the interplay of protein production and aggregation† Protein aggregation is a key process in the development of many neurodegenerative disorders, including dementias such as Alzheimer's disease.

Apr 22, 2024 | pubs.rsc.org | Alexander J. Dear |Lensfield Road |Xiangyu Teng |Sarah Ball

Molecular mechanism of α-synuclein aggregation on lipid membranes revealed† The central hallmark of Parkinson's disease pathology is the aggregation of the α-synuclein protein, which, in its healthy form, is associated with lipid membranes. Purified monomeric α-synuclein is relatively stable in vitro, but its aggregation can be triggered by the presence of lipid vesicles.

Oct 23, 2023 | biorxiv.org | Alexander J. Dear |Xiangyu Teng |Sarah Ball |Joshua Lewin

AbstractThe central hallmark of Parkinson's disease pathology is the aggregation of the α-synuclein protein, which, in its healthy form, is associated with lipid membranes. Purified monomeric α-synuclein is relatively stable in vitro, but its aggregation can be triggered by the presence of lipid vesicles. Despite this central importance of lipids in the context of α-synuclein aggregation, their mechanistic role in this process has not been established to date.