Alexander James Zwetsloot

Oct 26, 2023 | biorxiv.org | Ferdos Abid Ali |Alexander James Zwetsloot |Caroline Stone |Tomos Morgan

AbstractCellular cargos move bidirectionally on microtubules due to the presence of opposite polarity motors dynein and kinesin. Many studies show these motors are co-dependent, whereby one requires the activity of the other, although the mechanism is unknown. Here, using in vitro motility assays, we show that the kinesin-3 KIF1C acts both as an activator and a processivity factor for dynein.