Alexander Schleiffer

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A genome-wide screen identifies silencers with distinct chromatin properties and mechanisms of repression

Nov 20, 2024 | cell.com | Lorena Hofbauer |Lisa-Marie Pleyer |Franziska Reiter |Alexander Schleiffer |Anna Vlasova |Leonid Serebreni | +2 more

Keywordscis-regulatory DNA elementssilencershigh-throughput reporter screenstranscriptional repressiontranscription factorstranscription co-factorsprotein domain analysisDrosophila melanogasterIntroductionMulticellular organisms rely on precise activation and repression of distinct sets of genes according to cell type and extra- or intracellular signals during both development and throughout adult homeostasis.

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