Alexios Matikas

Mar 10, 2025 | biorxiv.org | Miguel Aguirre |Alexios Matikas |Linda S. Lindström |Nicholas P. Tobin

AbstractBreast tumors have traditionally been categorized into four widely recognized subtypes. Recent single-cell advancements have however shown that individual tumors can contain more than one subtype, exhibiting their intrinsic heterogeneity. Relatedly, whilst the crucial role of cell cycle regulation in cancer development is widely acknowledged, the specific impact of cell cycle phases on oncogenic signaling and processes in each of these subtypes remains unresolved.