Alfredo Sanchez

Nov 30, 2024 | mdpi.com | Alfredo Garcia |Alfredo García |Serguei Maximov |Alfredo Sanchez |Alfredo Sánchez |José G. Tirado-Serrato

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Nov 23, 2024 | academic.oup.com | Alfredo Sanchez |Alfredo Sánchez |Suez Canal

Transmural pressure and shear stress are mechanical forces that profoundly affect the smooth muscle cells (SMCs) comprising the vascular wall and the endothelial cells (ECs) lining the lumen. Pressure and flow are detected by mechanosensors in these cells and translated into appropriate responses to regulate blood pressure and flow. This review focuses on the role of the transient receptor potential (TRP) superfamily of cation channels in this process.