Alicja Tadych

Mar 19, 2024 | biorxiv.org | Victoria Li |Alicja Tadych |Aaron Wong

AbstractCRISPR/Cas9 is a genome editing tool widely used in biological research and clinical therapeutics. Natural human genetic variations, through altering the sequence context of CRISPR/Cas9 target regions, can significantly affect its DNA repair outcomes and ultimately lead to different editing efficiencies. However, these effects have not been systematically studied, even as CRISPR/Cas9 is broadly applied to primary cells and patient samples that harbor such genetic diversity.

Sep 27, 2023 | biorxiv.org | Victoria Li |Alicja Tadych |Aaron Wong

AbstractCRISPR/Cas9 is a genome editing tool widely used in biological research and clinical therapeutics. Naturally occurring human genomic variations, through altering the sequence context of CRISPR/Cas9 target regions, can significantly affect its DNA repair outcomes and ultimately lead to different editing efficiencies.