Aline Renneville

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Targeting heterochromatin eliminates chronic myelomonocytic leukemia malignant stem cells through reactivation of retroelements and immune pathways - Communications Biology

Nov 21, 2024 | nature.com | Vincent Alcazer |Stéphane Depil |Aline Renneville |Dorothée Selimoglu-Buet |Raphael Itzykson |Lucie Laplane | +3 more

AbstractChronic myelomonocytic leukemia (CMML) is a severe myeloid malignancy affecting the elderly, for which therapeutic options are limited. DNA hypomethylating agents (HMAs) provide transient responses, failing to eradicate the malignant clone. Hematopoietic stem cell (HSC) aging involves heterochromatin reorganization, evidenced by alterations in histone marks H3K9me2 and H3K9me3. These repressive marks together with DNA methylation are essential for suppressing transposable elements (TEs).

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