Alisha Crider

Jul 10, 2024 | biorxiv.org | Alicia Susana Haydo |Jennifer Schmidt |Alisha Crider |Tim Kögler

AbstractGlioblastoma (GBM), the most malignant primary brain tumor in adults, has a poor prognosis due to its radio-resistance and infiltrative growth. Our study assessed the functions and potential druggability of BRCA1-associated Ataxia telangiectasia mutated (ATM)-activator 1 (BRAT1) in GBM, focusing on DNA damage response and tumor migration.