Alison Ciling

Nov 21, 2024 | journals.plos.org | Abdullah M. Syed |Alison Ciling |PLOS Pathogens

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Syed AM, Ciling A, Chen IP, Carlson CR, Adly AN, Martin HS, et al. (2024) SARS-CoV-2 evolution balances conflicting roles of N protein phosphorylation. PLoS Pathog 20(11): e1012741.

Oct 18, 2023 | jbc.org | Christopher Carlson |Alison Ciling |Jennifer Doudna

AbstractThe Nucleocapsid (N) protein of SARS-CoV-2 compacts the RNA genome into viral ribonucleoprotein (vRNP) complexes within virions. Assembly of vRNPs is inhibited by phosphorylation of the N protein SR region. Several SARS-CoV-2 variants of concern carry N protein mutations that reduce phosphorylation and enhance the efficiency of viral packaging.