Alissandra L. Hillis

May 14, 2024 | biorxiv.org | Alissandra L. Hillis |Tigist Y. Tamir |Grace Perry |John M. Asara

AbstractTyrosine phosphorylation of metabolic enzymes is an evolutionarily conserved post-translational modification that facilitates rapid and reversible modulation of enzyme activity, localization or function. Despite the high abundance of tyrosine phosphorylation events detected on metabolic enzymes in high-throughput mass spectrometry-based studies, functional characterization of tyrosine phosphorylation sites has been limited to a subset of enzymes.