Allan S. Brett

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Articles

Does Vitamin D Supplementation Improve Physical Function in Generally Healthy Adults?

Jan 14, 2025 | jwatch.org | Allan S. Brett
Chlorthalidone vs. Hydrochlorothiazide for Hypertension: Renal Outcomes

Jan 7, 2025 | jwatch.org | Allan S. Brett
Coronary Calcium on CT Scans Done for Lung Cancer Screening

Jan 7, 2025 | jwatch.org | Allan S. Brett
Year in Review 2024

Dec 31, 2024 | jwatch.org | Allan S. Brett

The most important medical topics of 2024, as chosen by the editors of NEJM Journal Watch General MedicineIn the annual review of important clinical research - most of which was summarized in during 2024 - we are guided by relevance to general medical practice and recognition of landmark studies and key guidelines. Our editors have chosen topics that we believe will interest most clinicians who see adult patients, regardless of practice setting.
A Synopsis of Other Important Outpatient Research from 2024

Dec 30, 2024 | jwatch.org | Allan S. Brett

Allan S. Brett, MD In 2024, NEJM Journal Watch covered many studies that are not included in our detailed Year in Review feature but still were important contributions to the outpatient literature. Here are brief synopses of some of those studies. In two large, randomized trials from China, researchers compared systolic blood pressure (BP) targets of <120 mm Hg and <140 mm Hg in patients at high cardiovascular risk; one trial included only patients with diabetes.
Is Perioperative Use of GLP-1 Agonists Safe?

Dec 30, 2024 | jwatch.org | Allan S. Brett

Allan S. Brett, MD A new multisociety document provides some guidance on this controversy. Use of glucagon-like peptide-1 (GLP-1)-receptor agonists prior to procedures that involve sedation or general anesthesia has become a controversial topic. The concern is that GLP-1 agonists, which delay gastric emptying, might be associated with risk for periprocedural pulmonary aspiration.
A New Cardiovascular Risk Calculator

Dec 30, 2024 | jwatch.org | Allan S. Brett

Allan S. Brett, MD For most patients, this calculator provides substantially lower risk estimates than the previous American Heart Association calculator. In the past year, the American Heart Association (AHA) released a new cardiovascular risk calculator with the acronym PREVENT. It differs in several ways from the previous calculator, issued by the AHA and American College of Cardiology (ACC) in 2013.
Could the Screening Interval After Negative Colonoscopy Be Extended Beyond 10 Years?

Dec 19, 2024 | jwatch.org | Allan S. Brett

Allan S. Brett, MD, reviewing Studies suggest that a longer interval would be reasonable, especially in people at lower risk. Because randomized comparisons of intervals for screening colonoscopy are not feasible, recommendations are informed by observational data. Growing evidence suggests that the guideline-recommended 10-year interval after negative colonoscopy could be extended, with minimal effect on colorectal cancer (CRC) outcomes. Two new retrospective studies provide additional information.
Intensive vs. Standard Blood Pressure Lowering in Patients with Diabetes

Nov 21, 2024 | jwatch.org | Allan S. Brett
Tirzepatide in Patients with Obesity and Prediabetes

Nov 21, 2024 | jwatch.org | Allan S. Brett