Allende Miguelez-Crespo

Jul 3, 2024 | joe.bioscientifica.com | Elisa Villalobos |Allende Miguelez-Crespo |Ruth Morgan |Lisa Ivatt

Keywords: glucocorticoids; steroids; transport; metabolism; obesity; homeostasisIntroductionGlucocorticoids are required to maintain glucose and lipid homeostasis in times of physiological stress, ensuring an adequate fuel supply for the body (Kuo et al. 2015). In key metabolic tissues such as adipose tissue, skeletal muscle and liver, glucocorticoids act to prevent glycolysis and instead promote gluconeogenesis (Kuo et al. 2013).

Jan 26, 2024 | biorxiv.org | Elisa Villalobos |Ruth Morgan |Allende Miguelez-Crespo |Lisa Ivatt

AbstractGlucocorticoids modulate glucose homeostasis, acting on metabolically active tissues such as liver, skeletal muscle, and adipose tissue. Intra-cellular regulation of glucocorticoid action in adipose tissue impacts metabolic responses to obesity. ATP-Binding Cassette Family C member 1 (ABCC1) is a transmembrane glucocorticoid transporter known to limit the accumulation of exogenously administered corticosterone in adipose tissue.