Alma Sophia Barisaac

May 4, 2024 | biorxiv.org | Ziv Cohen |Alma Sophia Barisaac |Enas R. Abu-Zhayia |Ekaterina Petrenko

AbstractSynthetic lethality represents a promising therapeutic approach in precision oncology, exploiting genetic vulnerabilities that are exclusive to tumor cells while sparing normal tissues. By targeting non-oncogenic partners of mutated genes that cancers become dependent on, synthetic lethal interactions provide a strategy to selectively kill cancer cells.