Alsu Missarova

Jul 18, 2024 | genomebiology.biomedcentral.com | Alsu Missarova |Emma Dann |Leah Rosen |Rahul Satija

miloDE is a cluster-free framework for differential expression (DE) testing that leverages a graph representation of scRNA-seq data (Fig. 1). To construct a graph recapitulating distances between cells, we require count matrices and a pre-calculated joint latent embedding across all the replicates from tested conditions (Fig. 1, step 1).