Amanda Everitt

Nov 7, 2024 | biorxiv.org | Ketrin Gjoni |Xingjie Ren |Amanda Everitt |Yin Shen

AbstractThree-dimensional genome organization plays a critical role in gene regulation, and disruptions can lead to developmental disorders by altering the contact between genes and their distal regulatory elements. Structural variants (SVs) can disturb local genome organization, such as the merging of topologically associating domains upon boundary deletion. Testing large numbers of SVs experimentally for their effects on chromatin structure and gene expression is time and cost prohibitive.

Sep 26, 2024 | biorxiv.org | Ruchira Sharma |Kristen M. Berendzen |Amanda Everitt |Belinda Wang

AbstractOxytocin receptor (Oxtr) signaling influences complex social behaviors in diverse species, including social monogamy in prairie voles. How Oxtr regulates specific components of social attachment behaviors and the neural mechanisms mediating them remains unknown. Here, we examine prairie voles lacking Oxtr and demonstrate that pair bonding comprises distinct behavioral modules: the preference for a bonded partner, and the rejection of novel potential mates.

Sep 26, 2024 | biorxiv.org | Ruchira Sharma |Kristen M. Berendzen |Amanda Everitt |Belinda Wang

AbstractOxytocin receptor (Oxtr) signaling influences complex social behaviors in diverse species, including social monogamy in prairie voles. How Oxtr regulates specific components of social attachment behaviors and the neural mechanisms mediating them remains unknown. Here, we examine prairie voles lacking Oxtr and demonstrate that pair bonding comprises distinct behavioral modules: the preference for a bonded partner, and the rejection of novel potential mates.