Amanda L Pasqualini

2 weeks ago | biorxiv.org | Carrie Stine |David Marcus |Amanda L Pasqualini |Ananya Achanta

AbstractNociceptin/orphanin FQ (N/OFQ), an endogenous opioid neuropeptide, and its G-protein coupled receptor NOPR have been implicated in motivation, feeding behaviors, and aversion. Stress-induced dysfunction in these states is central to the development of numerous psychiatric disorders, and the N/OFQ-NOPR system′s role in reward- and stress-related responses has driven broad interest in NOPR as a therapeutic target for anxiety and depression.