Amelia V Schueppert

Aug 26, 2024 | biorxiv.org | Adam Rubin |Aviv Regev |Tyler T Dao |Amelia V Schueppert

AbstractImmune cells transduce environmental stimuli into responses essential for host health via complex signaling cascades. T cells, in particular, leverage their unique T cell receptors (TCRs) to detect specific Human Leukocyte Antigen (HLA)-presented peptides. TCR activation is then relayed via linker for activation of T cells (LAT), a TCR-proximal disordered adapter protein, which organizes protein partners and mediates the propagation of signals down diverse pathways including NFAT and AP-1.