Ami Mange

Dec 19, 2023 | onlinelibrary.wiley.com | Kelly Dunn |Andrew S. Huhn |Patrick Finan |Ami Mange

1 INTRODUCTION Only 12% of the estimated >10 million persons in the United States who report lifetime use of an opioid develop opioid use disorder (OUD),1 suggesting only a subgroup of persons who are exposed to opioids develop problematic opioid use behaviours.2 To date, there have been limited evaluations of opioid response profiles; however, existing clinical reports3 and laboratory studies4-7 suggest that some individuals demonstrate dose-dependent responses to opioids whereas other...