Anastasiya Buzuk

1 month ago | biorxiv.org | Anastasiya Buzuk |Melissa Márquez |Jackson Ho |Yaxi Liu

AbstractThe cytosolic iron-sulfur cluster assembly (CIA) targeting complex is responsible for maturation of cytosolic and nuclear iron-sulfur enzymes, numbering >30 proteins critical for fundamental processes such as DNA replication and repair. Up to 25% of these client proteins terminate in a targeting complex recognition (TCR) motif. This carboxy-terminal tripeptide motif recruits the CIA targeting complex (CTC) to the client so that the metallocluster can be inserted.