Anay Gupta

May 16, 2024 | biorxiv.org | Avantika Lal |Laura M Gunsalus |Anay Gupta |Tommaso Biancalani

AbstractThe design of regulatory elements is pivotal in gene and cell therapy, where DNA sequences are engineered to drive elevated and cell-type specific expression. However, the systematic assessment of synthetic DNA sequences without robust metrics and easy-to-use software remains challenging.

Nov 27, 2023 | biorxiv.org | Avantika Lal |Laura M Gunsalus |Tommaso Biancalani |Anay Gupta

AbstractThe design of regulatory elements is pivotal in numerous therapeutic interventions, including gene and cell therapy, wherein the typical objective is to engineer DNA sequences exhibiting specific attributes like cell-type specificity and elevated expression levels. However, the systematic assessment of these constructed DNA sequences remains challenging due to the absence of robust metrics and an integrated software framework.