Anders Albrechtsen

Aug 18, 2024 | biorxiv.org | Zilong Li |Anders Albrechtsen |Robert Davies

AbstractInexpensive and accurate genotyping methods are essential to modern genomics and health risk prediction. Here we introduce QUILT2, a scalable read-aware imputation method that can efficiently use biobank scale haplotype reference panels. This allows for fast and accurate imputation using short reads, as well as long reads (e.g. ONT 1X r2 = 0.937 at common SNPs), linked-reads and ancient DNA.