Andrea Liu

Oct 22, 2024 | go.aps.org | John Crocker |Andrea Liu

Biopolymer networks from the intracellular to tissue scale display high rigidity and tensile stress while having coordinations well below the normal threshold for mechanical rigidity. The elastic filaments in these networks are often severed by enzymes in a tension-inhibited manner. The effects of such pruning on the mechanics of prestressed networks have not been studied. We show that networks pruned by a tension-inhibited method remain rigid at much lower coordinations than randomly pruned ones.

Sep 26, 2024 | biorxiv.org | Kentson Lam |Yoon Kim |Andrea Liu |Carlo M Ong

AbstractOncogenic growth places great strain and dependence on the proteostasis network. This has made proteostasis pathways attractive therapeutic targets in cancer, but efforts to drug these pathways have yielded disappointing clinical outcomes. One exception is proteasome inhibitors, which are approved for frontline treatment of multiple myeloma.

Feb 21, 2024 | link.aps.org | Menachem Stern |Andrea Liu |Vijay Balasubramanian

Interacting many-body physical systems ranging from neural networks in the brain to folding proteins to self-modifying electrical circuits can learn to perform diverse tasks. This learning, both in nature and in engineered systems, can occur through evolutionary selection or through dynamical rules that drive active learning from experience. Here, we show that learning in linear physical networks with weak input signals leaves architectural imprints on the Hessian of a physical system.

Dec 20, 2023 | californiapolicycenter.org | Andrea Liu

This month, second-graders at Valencia Elementary in Upland were met with unwelcome news: the Christmas songs that they’d practiced for weeks would be replaced with new-and-improved non-holiday songs. No matter that these children had actually voted for their favorite Christmas tunes, or that they would have to learn an entirely new songbook in a matter of days. ”Frosty the Snowman” would be replaced with “BINGO,” and that was that. How did this decision come about?

Jun 26, 2023 | biorxiv.org | Menachem Stern |Andrea Liu |Vijay Balasubramanian

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