Andrea M. Dickey

Oct 19, 2023 | nature.com | Andrea M. Dickey |Stefan Knapp |Matthew D. Daugherty |Samara L. Reck-Peterson

AbstractLeucine Rich Repeat Kinase 1 and 2 (LRRK1 and LRRK2) are homologs in the ROCO family of proteins in humans. Despite their shared domain architecture and involvement in intracellular trafficking, their disease associations are strikingly different: LRRK2 is involved in familial Parkinson’s disease while LRRK1 is linked to bone diseases.