Andrea Prinzi

Sep 19, 2024 | asm.org | Andrea Prinzi |Rodney E. Rohde

Poliomyelitis is an ancient disease that has resulted in significant morbidity and mortality worldwide for centuries. Its history is complicated by changes in the way humans adapt and live, and advancements in prevention and treatment were fueled by human emotion and personal experience that have been rarely rivaled throughout history.

Jul 26, 2024 | asm.org | Andrea Prinzi |Rodney E. Rohde

Meningococcal meningitis is a potentially fatal bacterial infection of the brain and surrounding tissues that has been responsible for significant morbidity and mortality for hundreds of years. Today, sporadic and deadly outbreaks still occur, despite effective therapeutics and available vaccines. What is the story of meningococcal meningitis, and how has the disease continued to prevail despite technological advancements?

Apr 1, 2024 | phys.org | Andrea Prinzi

The unique regulatory environment for the clearance and use of antimicrobial susceptibility test (AST) systems is complex in the U.S. While members of the medical microbiology community recognize the importance of updating breakpoints for clinical and public health, there is a knowledge gap regarding the regulatory requirements for breakpoint updates and how these requirements impact the medical laboratory's update processes.

Mar 29, 2024 | asm.org | Andrea Prinzi

Device and Breakpoint Clearance at the FDA Two branches of the FDA are involved in clearing breakpoints for AST devices. The FDA Center for Drug Evaluation and Research (CDER) regulates antimicrobials and their associated breakpoints. In contrast, the FDA Center for Devices and Radiological Health regulates AST devices, including breakpoint implementation based on CDER-recommended breakpoints at the time of device clearance.

Sep 15, 2023 | asm.org | Andrea Prinzi |Rodney E. Rohde

Malaria, an infectious disease caused by parasites belonging to the Plasmodium genus and transmitted by infected mosquitoes, is responsible for mortality and morbidity in over 40% of the world, making it one of the most devastating diseases in human history. In fact, the disease is thought to be responsible for between 2-5% of all fatalities that occurred during the 20th century (between 150 million-300 million deaths).