Andrew Grigg

Dec 24, 2024 | onlinelibrary.wiley.com | Huyen Tran |Caroline Dix |Robert Bird |Sanjeev Chunilal |Tim Brighton |John Reynolds | +3 more

To the Editor, Immune thrombocytopenia (ITP) is an autoimmune disorder associated with the production of autoantibodies directed against platelet glycoprotein complexes, resulting in both accelerated destruction of platelets and a relative reduction in platelet production. In adults, the majority of the acute cases respond to initial steroid therapy, but 50% relapse by 6 months and an additional 25% relapse beyond 1 year [1].

Dec 11, 2024 | techuk.org | Andrew Grigg

Implement green AI practicesEducate AI and sustainability teams on the relationship between AI and environmental impact, and importantly on when and when not to use AI. Promote a culture of sustainability within the organisation by empowering all employees to take action and accountability for sustainability outcomes. Collaborate with the AI expert community to share best practices and innovations in sustainable AI.

Feb 25, 2024 | onlinelibrary.wiley.com | Andrew Grigg

Budesonide (Entocort) is a corticosteroid widely used as therapy for gut graft versus host disease (GVHD) in stem cell allograft patients. It undergoes extensive first-pass metabolism, and its high ratio of topical to systemic activity with minimally active metabolites means it is regarded as largely ‘non-absorbable’. This property is used to focus its anti-inflammatory effect in the gut and minimise the deleterious effects of systemic corticosteroid exposure.