Andrew Hill

Apr 1, 2024 | onlinelibrary.wiley.com | Jonathan Guo |Andrew Hill |Ibukunoluwa King |Jonathan Guo MBBS

1 INTRODUCTION CFTR modulators, and most notably the combination elexacaftor/tezacaftor/ivacaftor (ETI) have revolutionized the treatment of cystic fibrosis (CF), quickly becoming the international standard of care. Yet their prices have been set by the manufacturer, Vertex Pharmaceuticals, at hundreds of thousands of dollars per year.

May 18, 2023 | nature.com | Natalie B. Lister |Louise A. Baur |Andrew Hill |Claude Marcus |Thomas Reinehr

Treatment goalsTreatment should be centred on the individual and stigma-free (Box 1) and may aim for a reduction in overweight and improvement in associated comorbidities and health behaviours. Clinical considerations when determining a treatment approach should include age, severity of overweight and the presence of associated complications144,145.