Andrew Mason

Jan 16, 2025 | jci.org | Andrew Mason |Mohammed Osman |Elizabeth McCarthy |Doaa Waly

AbstractSuperantigen-induced (Sag-induced) autoimmunity has been proposed as a mechanism for many human disorders, without a clear understanding of the potential triggers. In this issue of the JCI, McCarthy and colleagues used the SKG mouse model of rheumatoid arthritis to characterize the role of Sag activity in inflammatory arthritis by profiling arthritogenic naive CD4+ T cells.